Functional expression of oligopeptide transporter PepT1 in the gastrointestinal tract and its regulatory factors
10.3760/cma.j.issn.1674-635X.2010.02.012
- VernacularTitle:寡肽转运体PepT1在胃肠道中的功能表达及调控因素
- Author:
Hongqi CHEN
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Oligopeptide;
Di/tri-peptide;
Intestinal tract;
Regulatory factors
- From:
Chinese Journal of Clinical Nutrition
2010;18(2):115-120
- CountryChina
- Language:Chinese
-
Abstract:
Many peptide transporters have been identified in mammals, among which PepT1 has been widely studied. PepT1, a member of proton-coupled oligopeptide transporter (POT) superfamily, is a peptide transporter of low affinity and high capacity and is mainly expressed in the brush border membrane of intestinal epithelial cells. PepT1 plays an important role in the absorption of di/tri-peptide (the degradation products of protein in intestinal tract). Meanwhile, it mediates the transport of peptide-like drugs and the bacterial products. Therefore,the changes of the functional expression of PepT1 in the gastrointestinal tract may dramatically affect the internal and external environmental stability and drug absorption. This paper reviews the structural features and function,distribution, transport mechanisms, and regulatory factors of PepT1.
