The association between heat-shock protein 70-2 gene + 1267A/G polymorphism and coronary heart disease

VernacularTitle:热休克蛋白70-2(HSP70-2)基因多态性与冠心病的相关性研究
Author: Chengcheng DUAN ; Qian CHEN ; Meimei ZHENG ; Fangjian WANG ; Yong JIANG ; Xiaohua PAN ; Liyan DONG
Publication Type:Journal Article
Keywords: HSP70 heat-shock proteins/ME/GE; Polymorphism,genetic; Coronary disease/ME/GE
From: Journal of Chinese Physician 2010;12(9):1194-1197
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between heat-shock protein 70-2 (HSP70-2) gene+1267A/G polymorphism and coronary heart disease (CHD) in Han Chinese population. Methods Using the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) , the polymorphism and genotype and allele distribution of HSP70-2 gene + 1267A/G in 185 CHD patients and 149 controls were analyzed. Results The HSP70-2 gene + 1267A/G polymorphism was found in this study population.The distribution of HSP70-2 genotypes was in Hardy-Weinberg equilibrium. The frequency of G allele in CHD group was significantly higher than that in control (61.89% vs51.68%, P ＜ 0. 01). After multiple logistic regression analysis, HSP70-2 gene (GG + AG) genotype was an independent risk factor of coronary heart disease. Conclusion HSP70-2 gene + 1267A/G polymorphism was associated with CHD risk of Han Chinese population, the G allele might serve as a genetic risk factor of coronary heart disease.