Clinical value of the plasma 1,3-β-D-glucan detection in the diagnosis of penicilliposis marneffei

VernacularTitle:血浆1,3-β-D-葡聚糖检测诊断播散性马尔尼菲青霉菌病的价值
Author: Yi LIANG ; Qi YIN ; Yong CHEN
Publication Type:Journal Article
Keywords: Penicilliposis marneffei; 1,3-β-D-glucan
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(18):2449-2451
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical value of the quantitative detection of plasma 1,3-β-D-glucan in penicilliposis marneffei. Methods The 1,3-β-D-glucan concentrations were detected by using a G test. Results In 60 New Zealand rabbits infected by Penicillium marneffei,the levels of 1,3-β-D-glucan were positively correlated with infectious severity. The sensitivity, specificity, positive predictive rate and negative predictive rate were 88.3%、100%、 100% and 58.8% respectively,which were significantly higher than those of the control group(P <0.01 ).Conclusion The quantitative method for the detection of 1,3-β-D-glucan in plasma was simple,sensitive and reliable, and could be used as the assisting diagnosis of penicilliposis marneffei at early stage.