Effect of different anesthetic techniques on perioperative changes in T-lymphocyte subsets in patients with cardia cancer
10.3760/cma.j.issn.1673-4904.2010.30.006
- VernacularTitle:两种不同的麻醉方法对贲门癌患者围手术期T淋巴细胞亚群的影响
- Author:
Xiaojia ZHANG
;
Qinqing HU
;
Hongqing LI
;
Minru DENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Anesthesia,epidural;
T-lymphocyte subsets
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(30):14-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of different anesthetic techniques on T-lymphocyte subsets in patients with cardia cancer. Methods Thirty-two patients undergoing elective radical operation for cardia cancer who had been average assigned into two groups by random digits table, group Ⅰ :general anesthesia;group Ⅱ :epidural anesthesia combined with general anesthesia (16 cases in each group).Peripheral blood T-lymphocyte subsets were measured before induction, after anesthesia, end of operation, 1d,3 d after operation. Results CD3,CD4,CD8 and CD4/CD8 all decreased in two groups after anesthesia,end of operation and 1 d after operation than before induction (P < 0.05). The index almost returned to the baseline values at 3 d after operation in group Ⅱ [ (60.75 ± 4.22 )%, (39.65 ± 3.64)%, (25.90 ± 1.17 )%,1.57 ±0.15](P >0.05),while in group Ⅰ still lower [(55.83 ±5.20)%, (35.15 ±5.65)%, (23.00 ±1.03 )%, 1.47 ± 0.35 ](P< 0.05 ). The two groups ontrast had significant deviation at 3 d after operation (P<0.05). Conclusion Epidural anesthesia combined with general anesthesia can reduce depression of Tlymphocyte subsets induced by surgical trauma and anesthesia.
