Reciprocal regulation between DNA methylation and mircoRNA
10.3760/cma.j.issn.1673-422X.2010.10.003
- VernacularTitle:DNA甲基化修饰与微小RNA的相互调控
- Author:
Lei CHENG
- Publication Type:Journal Article
- Keywords:
DNA methylation;
MicroRNAs;
DNA(Cytosine-5-)-methyltransferase;
Epigenesis
- From:
Journal of International Oncology
2010;37(10):728-731
- CountryChina
- Language:Chinese
-
Abstract:
Both DNA methylation and microRNAs(miRNA)play important roles in the development and progression of human cancer. Recently, it has been demonstrated that the promoter of miRNA can be methylated and DNA methylation can be regulated by miRNA through DNA methyltransferase. Research targeting this reciprocal regulatory mechanism may shed some light on the diagnosis and treatment of cancer.
