Medullary thyroid carcinoma and RET proto-oncogene
10.3760/cma.j.issn.1673-422X.2010.10.009
- VernacularTitle:甲状腺髓样癌与RET基因
- Author:
Junyi WANG
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Genes;
Mutation
- From:
Journal of International Oncology
2010;37(10):746-749
- CountryChina
- Language:Chinese
-
Abstract:
Medullary thyroid carcinoma originates from parafollicular cells. Its prognosis is worse than that of differentiated thyroid carcinoma. Surgery is the best treatment for early stage diseases. In the past decade, dominant activating mutations in the RET pro-oncogene have been identified as the main cause of MTC. Mutation analysis of the RET proto-oncogene has been used in the early diagnosis, prophylactic surgery and targeted therapy of MTC.
