Clinicopathologic features of post-transplant lymphoproliferative disorders
10.3760/cma.j.issn.0254-1785.2010.10.006
- VernacularTitle:肾移植后淋巴组织增生性疾病的临床和病理学特点
- Author:
Yinghao YU
;
Shuangyi FAN
;
Weizhen WU
- Publication Type:Journal Article
- Keywords:
Renal transplant;
Post-transplant lymphoproliferative disorders;
Morphologic categories;
Diagnosis;
Treatment
- From:
Chinese Journal of Organ Transplantation
2010;31(10):598-601
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the clinicopathologic features of post-transplant lymphoproliferative disorders (PTLD).Methods Three cases of PTLD in renal transplant recipients were studied.The clinical data,diagnosis and differential diagnosis,and relevant literatures were also reviewed.Results All the 3 cases studied had received cyclosporine A or Tac after transplantation.The duration between organ transplantation and diagnosis of PTLD was 10 years,4 years and 2 months respectively.Two cases were suffered from monomorphic PTLD and 1 from plasmacytic hyperplasialike PTLD in morphology.Two cases of monomorphic PTLD died within one year after diagnosis.Conclusion PTLD is a lymphoproliferative disease with distinctive morphologic and clinical characteristics.The main treatments included the dosage reduction of immunosuppressive agents,radiotherapy and chemotherapy.The prognosis of monomorphic PTLD was poor.
