Systematic review on vitamin D preventing and treating bone loss in renal transplant patients
10.3760/cma.j.issn.0254-1785.2010.10.007
- VernacularTitle:维生素D预防和治疗肾移植术后骨质疏松的系统评价
- Author:
Yingming XIAO
;
Xianding WANG
;
Zhiyuan XIE
;
Ke WU
;
Libo XIE
;
Yiping LU
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Vitamin D;
Osteoporosis;
Systematic review
- From:
Chinese Journal of Organ Transplantation
2010;31(10):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effectiveness and safety of vitamin D in preventing and treating bone loss in renal transplant patients.Methods Methods recommended by the Cochrane Collaboration were used.MEDLINE,EMBase,Cochrane Library and CNKI were searched from Jan.1990 to Nov.2009 to locate all the randomized controlled trials (RCT) concerning preventing and treating bone loss by vitamin D in renal transplant patients.The qualities of included trials were evaluated by two independent reviewers.Trails consistent with criteria wereanalyzed by Revman 4.2 software.Results Nine RCTs involving 658 post transplant patients were included.The qualities of included trials were graded as grade A in 4,grade B in 2 and grade C in 3.Meta-analysis showed that after being treated with vitamin D for one year,the difference of BMD,Z-score and T-score between the two groups was statistically significant (P＜ 0.05); the difference of PTH concentration was also statistically significant (P＜0.01),but there was no significant difference in concentrations of serum calcium and phosphorus,and the incidence of hypercalcemia (P＞0.05).Conclusion Current available evidence demonstrates that vitamin D is effective and safe in preventing and treating bone loss in renal transplant patients.
