A prospective case-control study of the ERPs in depression
10.3760/cma.j.issn.1674-6554.2010.10.014
- VernacularTitle:抑郁症事件相关电位的前瞻性病例对照研究
- Author:
Yan SUN
;
Li LI
;
Kewen WU
;
Huijun DUAN
;
Weidong SHANG
;
Yanfang WANG
;
Juyi PENG
;
Jintang MA
;
Kerang ZHANG
- Publication Type:Journal Article
- Keywords:
Depression;
Event related potential;
Citalopram
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(10):904-906
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the event-related potentials (ERPs) P300 is changeable or not before and after treatment. Methods 99 cases of patients with first onset of depression diagnosed by DSM-Ⅳ as case group,and 100 cases matched with patients as control group were collected. P300 of two groups were obtained before and after treatment for 6 weeks,12 weeks,24 weeks. T test was used to analysis the difference of indicators of P300 among groups; repeated measure analysis of variance was used to analysis the longitudinal changes. Results shorter latency of N2-P3 ( (P ＜ 0.01 ); and lower amplitude of N2, P3, N2-P3 (P ＜ 0. 05 ), higher amplitude of P2-tency and a upward one in N2-P3 latency in the four periods; a upward trend could also be found in P3, N2-P3 amplitude, but there were no statistical differences(P ＞ 0. 05 ). The results of paired-samples t test: P3, N2-P3 amplitude in case group were higher after treatment for 6 weeks than before, the difference was significant (P ＜ 0.01 ); no significant results were found in P300 latency or amplitude between the 62 cases of depression after treatment for 24 weeks and the 65 normal controls selected (P ＞ 0. 05 ). Conclusion P300 latencies and amplitudes tend to be partly recovered after the acute treatment in patients with depression, but after the long-term therapy not clear.
