Research advances in the relationship between nuclear factor-kappa B and hepatitis virus-associated cancers
10.3760/cma.j.issn.1673-422X.2010.10.016
- VernacularTitle:转录核因子-κB在肝炎病毒相关性肿瘤中的研究进展
- Author:
Yonggang LIU
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Neoplasms;
Hepatitis virus
- From:
Journal of International Oncology
2010;37(10):768-770
- CountryChina
- Language:Chinese
-
Abstract:
NF-κB is a key regulator in inflammation-associated tumors. Constitutively activated NF-κB participates in the development of many hepatitis virus-associated cancers(hepatocellular carcinoma, cholangiocarcinoma). Inhibition of NF-κB's activity can effectively slow or stop cancer growth and metastasis and enhance cancer cells' sensitivity to chemotherapy. Thus, NF-κB may become an effective therapeutic target in hepatitis virus-associated cancers in the near future.
