Expression of annexin A1 and PCNA in pancreatic cancer and their correlation
10.3760/cma.j.issn.1674-1935.2010.05.007
- VernacularTitle:膜联蛋白A1和增殖细胞核抗原在胰腺癌组织中的表达及其相互关系
- Author:
Xiaoguang NI
;
Xiaofeng BAI
;
Guiqi WANG
;
Shangmei LIU
;
Bing GUO
;
Ping ZHAO
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Annexin A1;
Proliferating cell nuclear antigen;
Tissue microarray
- From:
Chinese Journal of Pancreatology
2010;10(5):326-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of the annexin A1 ( ANXA1 ) in pancreatic cancer and the correlations with proliferating cell nuclear antigen (PCNA). Methods Tissue microarray instrument was used to construct the chip. There were 39 samples of normal pancreas tissue, 42 samples of pancreatic cancer, 7 samples of islet cell tumor and 8 samples of ampullary carcinoma. The expressions of ANXA1 and PCNA protein were examined by immunohistochemistry and their correlation was analyzed. Results The off-chip rate of tissue chips after immunohistochemistry was 11.7% ～ 13.3%, which could satisfy the needs for experiment. Immunohistochemical results of pancreatic cancer tissue microarray showed that the positive rate of ANXA1 expression in pancreatic cancer was 71.4% (30/42), which was significantly higher when compared with that of normal pancreas tissue ( 18.4%, 7/38; P < 0. 01 ). The positive rate of PCNA expression in pancreatic cancer was 73.8% (31/42), which was significantly higher than that of normal pancreas tissue (22.2%, 8/36; P < 0.01 ). The expression of ANXA1 had a significant correlation with PCNA in pancreatic cancer ( P < 0.01 ). Conclusions The expression of ANXA1 protein was significantly increased in pancreatic cancer. The expression of ANXA1 was significantly correlated with the expression of PCNA.
