Association of TCF7L2 gene rs290487 polymorphism and polycystic ovarian syndrome in Hans in Anhui Province

VernacularTitle:转录因子7样2基因rs290487多态性与安徽地区汉族人群多囊卵巢综合征的相关性
Author: Guoxi JIN ; Yaxin BI ; Lei YU ; Youmin WANG
Publication Type:Journal Article
Keywords: Polycystic ovarian syndrome; Transcription factor 7-like 2 gene; Insulin resistance
From: Chinese Journal of Endocrinology and Metabolism 2010;26(10):868-870
CountryChina
Language:Chinese
Abstract: One-hundred and sixty-nine women with polycystic ovarian syndrome (PCOS)and 95 healthy women were enrolled. All subjects were genotyped for rs290487 ( transcription factor 7-like 2 gene) by TaqManMGB probe hybridization assay. The results showed that polymorphism rs290487 had association with PCOS in Han people in Anhui area. The allele C was associated with the risk of PCOS. Genotype CC seems to be the risk factor of insulin resistance in PCOS patients.