Studying the conversion of artemisinin into azaartemisinin derivatives
- Author:
Phan Dinh Chau
- Publication Type:Journal Article
- Keywords:
Artemisinin, azaartemisinin
- MeSH:
Artemisinins;
Malaria
- From:Pharmaceutical Journal
2005;0(12):11-13
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Studying semi synthesis of some substances which contains lactam frame of artemisinin is 11-azaartemisinin, by let artemisinin interact with ammoniac or 3 amino including n-polyamine, n-butylamin and allylamin. The first step which was opening lacton circle to create amids occurred very fast within 30-45 minutes at room temperature. The second step which was closing circle occurred relatively low, usually 20-25 hours with the presence of strong acid catalyst. The higher temperature was, the lower the rates of 11-azaartemisinin derivatives were. The study was successful in transforming artemisinin into 11-azaartemisinin derivatives
