Application of propranolol in women with hyperthyroidism during pregnancy and lactation
10.3760/cma.j.issn.1000-6699.2010.10.025
- VernacularTitle:普萘洛尔在甲状腺功能亢进症孕产妇中的应用
- Author:
Yu YANG
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Propranolol;
Hyperthyroidism;
Pregnancy;
Lactation;
Application
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(10):907-909
- CountryChina
- Language:Chinese
-
Abstract:
Physicians often encounter patients with both hyperthyroidism and pregnancy in clinical practice. Proper treatment will help a lot for both mother and fetus. However, whether propranolol could be applied routinely in the medical therapy other than antithyroid drugs is not regularly mentioned in text book, because there were few literatures reporting its side effects including miscarrage, intrauterine growth retardation, bradycardia, respiratory depression, hypoglycemia, and hyperbilirubinemia. Animal experiments revealed bradycardia after propranolol administration, and respiratory depression after birth due to blockage of β receptors in the lungs. Nevertheless, this drug has been considered safe in pregnant hyperthyroid women according to long-term experience, as no malformation has been demonstrated in the offsprings, and it helps a lot in hyperemesis gravidarum as well. Specialists also recommend short-term use like a few weeks before antithyroid drugs set in action and during thyroid storm, in order to avoid potential side effects. It is suggested that less than routine-dose of the drug be administered before labor, as the plasma drug concentration in the neonate would elevate after birth. As for lactating mother, it's safe to take regular dose of the drug because only extremely low dose will be taken by the neonate through milk.
