DNA methyltransferases in cancer development, treatment and prognosis
10.3760/cma.j.issn.1673-422X.2010.10.004
- VernacularTitle:DNA甲基转移酶在肿瘤发生预后治疗中的作用
- Author:
Di CHENG
- Publication Type:Journal Article
- Keywords:
DNA(Cytosine-5-)-Methyltransferase;
DNA methylation;
Neoplasms
- From:
Journal of International Oncology
2010;37(10):731-734
- CountryChina
- Language:Chinese
-
Abstract:
Overexpression of DNA methyltransferases(DNMTs)is observed in many tumors. Overexpressed DNMTs silence tumor suppressor genes by catalyzing the methylation of CpG islands within the promoter regions, and therefore promote the neoplastic transformation of normal cells. Highly elevated DNMT activities have been observed in cancers including gastrointestinal cancers, breast cancer, and lung cancer and have been associated with cancer development and prognosis. Drugs and targeted therapies that inhibit DNMT activities can reactivate methylated tumor suppressor genes, promote apoptosis, and thus inhibit tumor growth.
