Clinical applications of strontium-89 therapy for bone metastases of lung cancer

VernacularTitle:89锶治疗肺癌多发性骨转移的临床应用
Author: Mei LI
Publication Type:Journal Article
Keywords: Strontium; Radiotherapy; Lung neoplasm; Bone neoplasms
From: Journal of International Oncology 2010;37(10):765-767
CountryChina
Language:Chinese
Abstract: Strontium-89(89Sr)therapy has been recognized as an effective method for treating bone metastases. It functions as a calcium analog that binds with collagen matrix produced by the MC3T3-E1 cells during collagen mineralization. 89Sr emits pure β rays which palliate bone pains and reduce the number of new metastasis sites. Response to 89Sr is affected by factors such as the location, size and histological type of lung cancer, the type of metastasis and the duration of treatment, and can be predicted by relief of bone pain, elimination of metastasis, CD4 +/CD8 +, ALP, and others. 89Sr therapy is safe and effective. Repeat administration or combined used with other treatments can improve the therapeutic effect of 89Sr.