Advances in staging and prognosis of NK/T-cell lymphoma
10.3760/cma.j.issn.1673-422X.2010.10.021
- VernacularTitle:NK/T细胞淋巴瘤分期及预后研究进展
- Author:
Xiaofang WANG
- Publication Type:Journal Article
- Keywords:
Killer cells,natural;
Lymphoma,T-cell;
Staging;
Prognosis
- From:
Journal of International Oncology
2010;37(10):783-786
- CountryChina
- Language:Chinese
-
Abstract:
NK/T-cell lymphoma(NTCL)can be classified into upper aerodigestive tract(UAT)NTCL and non-UAT NTCL. The Ann Arbor staging system is unsatisfactory for this lymphoma. A new staging system for NTCL is proposed:limited disease(stage Ⅰ/Ⅱ UAT-NTCL without local invasion)and extensive disease(stage Ⅰ/Ⅱ with local invasion or stage Ⅲ/Ⅳ disease of UAT NTCL, non-UAT NTCL). There is an ongoing debate regarding the use of the Ann Arbor staging and the International Prognostic Index for prognostic purposes in NK/T-cell lymphoma. Other factors, including tumor's local infiltration, Epstein-Barr virus, tumor biology and microenvironment, have also been found to affect the prognosis.
