Effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension

VernacularTitle:替米沙坦对高血压患者颈总动脉内膜中层厚度的影响
Author: Dongdan ZHENG ; Yujie LI ; Hongwu CHEN ; Xiuren GAO ; Lijuan LIU
Publication Type:Journal Article
Keywords: Hypertension; Carotid arterial intima-media thickness; Telmisartan; Ramipril
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(19):2593-2595
CountryChina
Language:Chinese
Abstract: Objective To investigate inhibitory effect of Telmisartan on carotid arterial intima-media thickness in patients with essential hypertension. Methods 104 patients with mild or mid essential hypertension were randomly divided into three groups, which include telmisartan group( telmisartan 80 mg/d PO), ramipril group( ramipril 5 mg/d PO), and control group( other anti-hypertension agents). Blood pressure was monitored during treatment. Carotid arterial intima-media thickness(CIMT) were measured in all patients at beginning and patients who had the 12 months course. Results There were 91 patients who had the 12 months course,which include telmisartan group33 cases,ramipril group28 cases, and control 30 cases. The CIMT was significantly decreased in telmisartan group and ramipril group ( all P < 0. 05 ), and not changed in control while blood pressure fall effectively. In ramipril, group5 cases were ceased the course because of severe cough. Conclusion Both telmisartan and ramipril could decrease blood pressure and CIMT effectively, and there were less side effects in telmisartan group.