Clinical significance of the expression of HIF-1α and VEGF gene in endometrial carcinoma tissue
10.3760/cma.j.issn.1008-6706.2010.20.010
- VernacularTitle:子宫内膜癌组织中缺氧诱导因子-1α、血管内皮生长因子基因表达的临床意义
- Author:
Xiaoxu GAO
- Publication Type:Journal Article
- Keywords:
Endometrial carcinoma;
HIF-1α;
VEGF
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(20):2759-2760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the expression of HIF-1 alpha,VEGF gene and cliulcal stage of endometrial cancer. Methods 30 patients with the membrane carcinoma were detected VEGF, HIF-1α expression by immunohistochemical method. The expression of different pathological type and clinical stage were analyzed. Another 10 pieces achieved from endometriosis dysplasia organization were taken as control. Results The positive rate of HIF-1 alpha, VEGF in endometriosis dysplasia and endometrial carcinoma were statistically significant differences( x2=11.87,8. 71, all P ＜ 0. 05 );There was correlated relationship between ultrasonic grading of tumor blood and HIF-1 alpha, VEGF; There was correlated relationship between Lesions and HIF-1 alpha, VEGF.Conclusion The expressions of HIF-1 alpha, VEGF were positively correlated to the degree,metastasis and prognosis of malignant endometrial carcinoma.
