Correlation between serum albumin level and intestinal mucosa change in rats with cerebral hemorrhage
10.3760/cma.j.issn.1006-7876.2010.11.017
- VernacularTitle:脑出血大鼠血清白蛋白水平与肠黏膜变化的关系
- Author:
Jianlin WANG
;
Suming ZHANG
;
Zhixiu YANG
;
Xiaomin ZHANG
;
Yunhu FAN
;
Jingmei WANG
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Serum albumin;
Intestinal mucosa;
Rats
- From:
Chinese Journal of Neurology
2010;43(11):801-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between the serum albumin level and the jejunal mucosal morphology in rats with cerebral hemorrhage and to find out the mechanism of the resulting hypoproteinemia.Methods A rat model of cerebral hemorrhage was used to detect the serum albumin level and the morphologic parameters of jejunal mucosa on day 1,7 and 14 after the hemorrhage.The results were compared to the normal control group and the sham-operated group. The correlation between the serum albumin level and the parameters of the jejunal mucosal morphology was explored.Results The serum albumin level was positively correlated with the small intestinal villous height(r =0.869,P＜0.01),villous area(r=0.659,P＜0.01),mucosal thickness (r=0.915,P＜0.01),depth of intestinal glands(r=0.545,P＜0.05)and density of intestinal glands(r=0.475,P＜0.05).Conclusion The serum albumin level is closely related to the morphologic changes of the jejunal mucosa.
