The influence of Clopidogrel combined with Aspirin in treatment of young people with cerebral artery stenosis and blood plasma P-selectin
10.3760/cma.j.issn.1008-6706.2010.19.008
- VernacularTitle:氯吡格雷联合阿司匹林治疗青年人血管狭窄性脑梗死及对血浆P-选择素的影响
- Author:
Jijun YIN
;
Chuanxian ZHU
- Publication Type:Journal Article
- Keywords:
Cerebral Infarction;
Clopidogrel;
Aspirin;
P-selectin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(19):2610-2612
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of Clopidogrel combined Aspirin to treat cerebral artery stenosis of young people and P-selectin in blood plasma. Methods 142 cases were randomly divided into therapy group (70 cases) and control group (72 cases). The two groups were given Aspirin ( 0. 1/d, Bayer company) by peroral administration or nasal feeding( deglutation disturbance) and simultaneously given tatin drug, Venoruton injection, Citicoline and Salvia Miltiorrhiza injection. The therapy group were added clopidogrel(75mg/d,Shenzhen Salubris Pharmaceuticals Co, Ltd). Venous blood was taken suction to detect platelet packing fraction, P-selectin and Doppler ultra-sound and carotid artery blood flow velocity before medication,24 hours after medication ,7 days after medication. Results Platelet packing fraction, P-selectin were significantiy decreased in the two groups than before treatment( P <0. 05)and therapy group were sigrificantly lower than control group( P < 0. 01 ). The control group after 7 days of treatment, transcranial Doppler ultrasound and carotid artery blood flow velocity significantly improved ( P < 0. 05 ), but the treatment group more significantly (P < 0. 01 ). Conclusion Blood plate was activated in patients of cerebral artery stenosis of young people, Clopidogrel combined with Aspirin could improve the blood rheology and hemodynamics, reduce the volume of cerebral lesions and improve the prognosis of patients.
