Risk factors of stroke-associated infection and their correlation with immunodepression
10.3760/cma.j.issn.1673-4165.2010.09.002
- VernacularTitle:卒中相关感染的危险因素及其与免疫抑制的相关性
- Author:
Lijuan YANG
;
Zhi GENG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Infarction;
Cerebral hemorrhage;
Infection;
Immunity,cellular;
Leukocyte count;
Lymphocytes;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2010;18(9):646-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of stroke-associated infection (SAI)and their correlation with immunodepression.Methods One hundred fourteen consecutive patients with acute ischemic stroke admitted with 24 hours after symptom onset were enrolled.They were divided into infection (n =45) and non-infection (n =69) groups according to whether they had infection or not within 7 days after admission.Automatic blood analyzer and flow cytometry were used to measure the peripheral blood lymphocyte count and T lymphocyte subsets on the day of admission.Univariate analysis and multivariate logistic regression analysis were used to analyze the related risk factors for SAI.Results There were statistical significances in vomiting,disturbance of consciousness,dysphagia,indwelling gastric tube,indwelling catheter on admission,and the National Institutes of Health Stroke Scale (NIHSS) score 0-3 days after admission between the infection and non-infection groups.Further more,the numbers of peripheral blood lymphocytes,CD3 + and CD4 + T lymphocytes in the infection group were significantly lower than those in the non-infection group.Multivariate logistic regression analysis showed that dysphagia,the increased NIHSS score 3 days after admission,and the decreased numbers of CD4 + T lymphocytes were the independent risk factors for SAI.Conclusions The T lymphocyte immune function decreased in patients with SAI.It was the result of the combined action of various factors.Targeted prevention and treatment should be taken to reduce the occurrence of SAI.
