Association study of schizophrenia and ankyrin repeat and kinase domain containing 1 gene polymorphism
10.3760/cma.j.issn.1674-6554.2010.10.017
- VernacularTitle:锚蛋白重复和激酶域1基因多态性与精神分裂症的关联研究
- Author:
Juan GUO
;
Yuantang CHEN
;
Changjiang HE
;
Li ZHANG
;
Yu WU
;
Yangling XING
;
Lei AO
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Ankyrin repeat and kinase domain containing 1;
Polymorphism;
Association analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(10):912-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the genetic association between schizophrenia and polymorphism of Ankyrin repeat and kinase domain containing 1 ( ANKK1 ) gene. Methods Observed in a sample of 112 parent/offspring trios where the proband net the American Classification and diagnostic Criteria for Mental Disorders The Forth Revised Edition, criteria for schizophrenia using correlation analysis and haplotype relative risk analysis. The polymorphism of Ankyrin repeat and kinase domain containing 1 gene was detected with PCR methods and SNP typing in all nucleus families. Results The rs2734849 allele was connected with schizophrenia(P= 0. 026). Allele T was protective factor( Z= -2.19) and allele A was the hazard factor( Z=2. 19). The rs4938015,rs7118900 and rs1800497 allele were independence with schizophrenia. Three kinds haplotypes of G/A in the rs7118900 -rs2734849, A/C in the rs2734849 -rs1800497, G/A/C in the rs7118900 -rs2734849 -rs1800497 were associated with schizophrenia ( The P values were 0.032,0. 041,0.046, the genotype frequencies were 0. 36,0.29,0. 17 ).Conclusion It shows an association between schizophrenia and the polymorphism at nucleotide of ankyrin repeat and kinase domain containing 1 gene in Chinese.
