Establishment of a canine model with acute thrombo-embolic pulmonary hypertension guided by echocardiography
10.3760/cma.j.issn.1004-4477.2010.10.024
- VernacularTitle:超声引导下犬自体血栓栓塞性急性肺动脉高压模型的建立及意义
- Author:
Dandan SUN
;
Hongmao CHEN
;
Yunyou DUAN
;
Fujun SHANG
;
Ningnan LIANG
;
Wei CAO
;
Xi LIU
;
Tiesheng CAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Pulmonary embolism;
Hypertension,pulmonary
- From:Chinese Journal of Ultrasonography
2010;19(10):893-896
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a canine model with acute thrombo-embolic pulmonary hypertension monitored by echocardiography. Methods Simulated the pathophysiologic process of acute thrombo-embolic pulmonary hypertension in human, the canine model was developed. The femoral vein puncture and the right heart catheterization to monitor pulmonary artery pressure were operated guided by echocardiography, while the autologous blood clot was injected to the contralateral femoral vein. The criteria of model was the pulmonary artery systolic pressure was higher than 30 mmHg. Results Echocardiography can accurately guide the placement of right heart catheterization and ancillarily observe the pressure testing of pulmonary artery. Of twenty seven healthy experiment dogs, twenty four models with acute thromboembolic pulmonary hypertension were successfully developed. The successful rate was 88.9 %. Conclusions This canine model with acute thrombo-embolic pulmonary hypertension guided by echocardiography is easy to operate and its repeatability is good.
