Clinical significance of preS1,HBV DNA and HBV-M in patients with chronic hepatitis B

VernacularTitle:乙型肝炎病毒前S1抗原与HBV DNA及血清标志物的关系
Author: Huixia MA ; Haiying JIA ; Yongfang TIAN ; Hongmei MO
Publication Type:Journal Article
Keywords: HBV PreS1-Ag; HBV DNA; HBV-M
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(20):2752-2754
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance and relationship of preS1, HBV DNA and HBV-M. Methods PreS1 and HBV-M was detected by ELISA method,and HBV DNA was detected by PCR. Then the results were analyzed. Results In HBV patients,the positive rates of preS1 and HBV DNA had no statistically significant ,they had fine dependability. The detection rate of preS1 in HBeAg(+) group(80.3%) and HBeAg(+)group( 56.3% ) had statistically significant. In some patients,though HBeAg had become negative, HBV still replicated. In HBV DNA replicated patients(≥103 copies/ml) ,the detection rate of HBeAg and preS1 were 51.5% and 70.9% ,they had statistically significant. Conclusion HBV DNA and PreS1 had fine dependability,preSl could reflect the replication of HBV sensitively than HBeAg,it could be used as a reliable new marker of HBV replication in vivo.