Effect of Probucol combined with Simvastatin Blood Levels of Oxidied Low Density Lipoprotein and Inflammatory Factors in Acute Stage of Cerebral Infarction
10.3760/cma.j.issn.1008-6706.2010.19.022
- VernacularTitle:普罗布考联合辛伐他汀对脑梗死患者急性期血清氧化低密度脂蛋白和炎性因子的影响
- Author:
Guangxia XU
;
Haixia LI
;
Wansheng CHANG
- Publication Type:Journal Article
- Keywords:
Cerebral Infarction;
Inflammatory factors;
Probucol
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(19):2640-2642
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of probucol combined with simvastatin on blood levels of oxidied low density lipoprotein (ox-LDL) and inflammatory factors in acute stage of cerebral infarction. Methods A total of 122 patients with acute stage of cerebral infarction were randomly divided into two groups:observation group ( n = 62),and control group( n = 60). After two weeks of follow-up ,the levels of high sensitivity C-reactive protein(hsCRP) ,oxLDL ,fibrinogen ( FIB ), interleukin 6 (IL-6) and blood lipids were detected. The side effect was recorded and the difference between two groups was analyzed. At 7 d and 14 d, curative effects were evaluated by standard scale of clinical neurological deficit. Results Compared with the control group, 2weeks after the medication, low-density lipoprotein cholesterol( LDL-C), apolipoprotein B ,ox-LDL, IL-6 and hsCRP were significantly decreased in the observation group (P <0.01 ). Conclusion The treafment of probucol combined with simvastatin could reduce the levels of ox-LDL and inflammatory factors in acute stage of cerebral infarction, and prevent hemorrhagic transformation and recurrence of cerebral in farction.
