Expression and clinical significance of CD44v3 and VEGF-C in gastric cancers
10.3760/cma.j.issn.1008-6706.2010.20.002
- VernacularTitle:黏附分子CD44v3和血管内皮生长因子C在胃癌组织中的表达及其意义
- Author:
Lin WANG
;
Zhongsheng XIA
;
Yunjie ZENG
;
Tingsheng PENG
;
Jun LV
;
Haigang LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Cell adhesion molecules;
Antigens,CD44;
Vascular endothelial growth factor C
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(20):2740-2742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of CD44v3 and VEGF-C in human gastric cancers and the clinical significance. Methods The expression of CD44v3 and VEGF-C was detected by immunohistochemistry SP method in 92 gastric cancer tissues. Results Positive immunohistochemical stain for CD44v3 was identified in 27.2% of gastric cancer tissues. There was no correlation found among the expression of CD44v3 with sex, location,depth of invasion, WHO type, Lauren type as well as distant metastasis (all P ＞ 0. 05 ). The expression of CD44v3 was positively correlated with lymph node metastasis and tumor differentiation( all P ＜ 0. 05 ). Positive immunohistochemical stain for VEGF-C was identified in 48.9% of gastric cancer tissues. There was no correlation found among the expression of VEGF-C with sex,location, tumor differentiation, depth of invasion, WHO type, as well as distant metastasis ( all P ＞ 0. 05 ). The expression of VEGF-C was positively correlated with lymph node metastasis and Lauren type ( all P ＜0. 05). Cox-Regression reflected that only the lymphatic metastasis situation correlated with the life ratio( P =0. 015). Conclusion The expression of CD44v3 and VEGF-C could suggest the progression and metastatic potential value of gastric cancer,but didnt correlate with the life ratio. There was no cooperation between CD44v3 and VEGF-C in promoting gastric cancer metastasis.
