The clinical research of restless leg syndrome and Parkinson's disease

VernacularTitle:不宁腿综合征与帕金森病的相关临床研究
Author: Luqing ZHAO ; Luning WANG ; Fengyun HU
Publication Type:Journal Article
Keywords: Restless legs syndrome; Parkinson's disease; Ferritins
From: Chinese Journal of Internal Medicine 2010;49(11):947-950
CountryChina
Language:Chinese
Abstract: Objectives To investigate the clinical feature of Parkinson's disease (PD) with restless leg syndrome (RLS) and the pathogenesis of RLS. Methods We conducted a cross-sectional and control study. The case group concluded 31 PD with RLS patients, meanwhile 39 PD patients were selected as the control group. Clinical history, clinical manifestations, complications and laboratory examinations were compared respectively between the two groups. Results All the RLS symptoms did not appear in RLS patients until the PD symptoms came out. Significant differences were found in complications such as swallow disturbance, constipation and illusion, when we compared the two PD groups (P ＜ 0.05 ). Compared with the PD or healthy group, the level of serum ferritin and the H-reflex latency of tibial nerve were significantly decreased in PD with RLS group ( P＜0.05). Conclusions Secondary RLS is a complication of PD.Deficiency of iron and decreased inhibition function of spinal cord may lead to the occurrence of RLS in PD patients. When their motor symptoms are serious and complications are more common, PD patients are more possible to have RLS symptoms.