The relationship of MMP-12 and the pulmonary disease
10.3760/cma.j.issn.1673-4408.2010.06.011
- VernacularTitle:MMP-12与肺部疾病的关系
- Author:
Ning YANG
- Publication Type:Journal Article
- Keywords:
Matrix matalloprotenases-12;
Extracellular matrix;
Pulmonary disease
- From:
International Journal of Pediatrics
2010;37(6):582-584
- CountryChina
- Language:Chinese
-
Abstract:
Matrix matalloprotenases-12(MMP-12) is a member of the matrix matalloprotenases family,and it is a main mediator to degradate the extracellular matrix. MMP-12 is composed of an propeptide domain, a catalytic domain and hemopexin-like domain. The function of MMP-12 include the genetic transcription and inhibitor regulation. Overexpress of MMP-12 causes pathological extracellular matrix protein breakdown and excessive airway remodeling,and MMP-12 is impotant in the pathogenesis of the acute and chronic lung injury,which has been implicated in a range of respiratory diseases, including asthma and emphysema.
