Role of Toll-like receptor 4 in intestinal ischemia-reperfusion and the interventional role of ω-3 polyunsaturated fatty acids
10.3760/cma.j.issn.1674-635X.2010.05.013
- VernacularTitle:肠道缺血再灌注时Toll样受体4的作用及ω-3多不饱和脂肪酸的干预
- Author:
Kaiguo ZHOU
;
Guizhen HE
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4;
Ischemia-reperfusion;
ω-3 polyunsaturated fatty acids
- From:
Chinese Journal of Clinical Nutrition
2010;18(5):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors is a super-family of pathogen recognition-receptors discovered in recent years.During the process of ischemia-reperfusion, the Toll-like receptor 4 (TLR4) combines with lipopolysaccharide and many endogenous ligands such as high mobility group protein B1, heparan sulfate, and fibrinogen. Through the myeloid differentiation protein 88 -dependent and -independent signaling pathways, the products induce the release of inflammatory cytokine-mediated inflammatory response, leading to injuries. ω-3 polyunsaturated fatty acids, by inhibiting the signal pathway activation and target gene expression of TLR4, can influence the function of many immune cells and regulate the body's inflammatory response and immune function. This article reviews the function of TLR4 during ischemia-reperfusion injury and the possible interventional role of ω-3 polyunsaturated fatty acids.
