Efficacy and adverse events of sevoflurane versus propofol combined anesthesia for induction of general anesthesia: a Meta-analysis
10.3760/cma.j.issn.0254-1416.2010.08.006
- VernacularTitle:七氟醚或异丙酚复合麻醉诱导效应和不良事件发生的比较:Meta分析
- Author:
Lin CHEN
;
Hong ZHENG
;
Jianrong YE
;
Lan ZHANG
;
Ming MA
;
Jin YU
- Publication Type:Journal Article
- Keywords:
Anesthetics,inhalation;
Propofol;
Anesthesia,general;
Meta-analysis
- From:
Chinese Journal of Anesthesiology
2010;30(8):913-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the efficacy and adverse events of sevoflurane or propofol combined anesthesia for induction of general anesthesia. Methods We searched the PubMed, OVID, EMBASE,Cochrane Library and Chinese Biomedical Database (CBM) for studies on efficacy of sevoflurane versus propofol for anesthesia induction. The quality of the studies was evaluated by the method recommended by Cochrane Collaboration. Meta-analysis was conducted using the Cochrane Collaboration's RevMan 4.2.8 software. Results Thirteen prospective randomized controlled trials involving 968 patients were included in our meta-analysis. The results showed that the time from onset of induction to loss of consciousness and the time for induction were significantly longer, the incidence of respiratory depression lower in S group than in P group. There were no significant differences in the incidence of adverse events during induction and success rate of inserting LMA at first attempt between the 2 groups. The incidence of adverse events with LMA insertion was significantly lower in S group than in P group. Conclusion Propofol combined anesthesia is suitable for rapid induction of anesthesia, and sevoflurane combined anesthesia is indicated for slow induction of anesthesia in patients with potential respiratory difficulty and for LMA insertion.
