The role of TGF-β/BMP signaling pathway in the development of cardiac outflow tract
10.3760/cma.j.issn.1673-4408.2010.06.001
- VernacularTitle:TGF-β/BMP信号通路在心脏流出道发育中的作用
- Author:
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Transforming growth factor β/ bone morphogenetic protein;
Signaling pathway;
Conotruncal anomaly;
Congenital heart diseases
- From:
International Journal of Pediatrics
2010;37(6):551-554
- CountryChina
- Language:Chinese
-
Abstract:
Conotruncal anomaly is composed of a group of complex congenital heart diseases. Cardiac outflow tract (OFT) plays an essential role in the cardiac conotruncal development. Recently, transforming growth factor β/bone morphogenetic protein signaling pathway has become a research hotspot, which is recognized as a important regulation mechanism in many processes of the cardiac development, such as separation of OFT and maturation of septums. In this paper we describe the role of the signaling pathway and its effect on the development of cardiac OFT.
