Ikaros and childhood acute lymphoblastic leukemia
10.3760/cma.j.issn.1673-4408.2010.06.003
- VernacularTitle:Ikaros基因与儿童急性淋巴细胞白血病预后的关系
- Author:
Fen ZHOU
- Publication Type:Journal Article
- Keywords:
Ikaros;
Gene deletion;
Dominant negative;
Acute lymphoblastic leukemia
- From:
International Journal of Pediatrics
2010;37(6):558-560
- CountryChina
- Language:Chinese
-
Abstract:
Ikaros is a transcriptional factor playing an essential role in lymphoid lineage development and differentiation. Ikaros gene deletions occur in some acute lymphoblastic leukemia (ALL) patients, and the most common type of abnormality is overexpression of dominant negative isoforms 6 (Ik6). Deletion of Ikaros gene has an independent association with a very poor outcome in B-cell-progenitor ALL. A new subtype of ALL characterized by the deletion of Ikaros and poor outcome has been identified by researchers, and named BCR/ABL1 like ALL.We can conclude that Ikaros may play an important role in the diagnosis and treatment of pediatric ALL.
