The relationship between the polymorphisms of RFC and methotrexate resistance
10.3760/cma.j.issn.1673-4408.2010.06.004
- VernacularTitle:还原性叶酸载体基因多态性与甲氨蝶呤药物敏感性的相关研究进展
- Author:
Wei ZHAO
- Publication Type:Journal Article
- Keywords:
Reduced folate carrier;
Gene polymorphism;
Gene expression;
Methotrexate;
Drug sensitivity
- From:
International Journal of Pediatrics
2010;37(6):561-564
- CountryChina
- Language:Chinese
-
Abstract:
The best characterized methotrexate (MTX) transporter is the reduced folate carrier (RFC),whose gene polymorphism is one of the reasons causing MTX resistance. Based on the studies in rencent years,we have known that synthesis of mutant RFC or loss of RFC transcripts and proteins results in antifolate resistance due to incomplete inhibition of cellular enzyme targets and insufficient substrate for polyglutamate synthesis. So additional human RFC structural and mechanistic studies are absolutely essential. This paper summarizes an association between the polymorphisms of RFC and MTX resistance, which can provide a basis for clinical treatment.
