Rhinovirus infection and acute exacerbation of asthma in children
10.3760/cma.j.issn.1673-4408.2010.06.009
- VernacularTitle:鼻病毒感染与儿童哮喘急性加重机制
- Author:
Ying PANG
- Publication Type:Journal Article
- Keywords:
Rhinovirus;
Asthma;
Acute exacerbation
- From:
International Journal of Pediatrics
2010;37(6):577-579
- CountryChina
- Language:Chinese
-
Abstract:
Human rhinovirus (HRV) infection is an important predisposing factor of acute asthma attacks and exacerbations, but the pathogenic mechanism is extremely complex. Inflammatory responses can be caused by the direct effect of rhinovirus and the release of inflammatory mediators and inflammatory cell infiltration. HRV infection stimulates the body's abnormal immune response, especially Thl / Th2 immune imbalance and dysfunction of regulatory T cells has attracted extensive attention. In-depth study in the pathogenic mechanism of acute asthma exacerbation induced by HRV infection in children is essential to elucidate the pathogenesis of asthma and to explore immunotherapy of asthma.
