Assessment of glomerular filtration rate in renal transplant recipients using serum cystatin C during follow-up
10.3760/cma.j.issn.0254-1785.2010.11.002
- VernacularTitle:肾移植术后随访中检测受者血清胱抑素C的临床价值
- Author:
Junsheng YE
;
Shaojie FU
;
Wenfeng DENG
;
Yun MIAO
;
Lixin YU
- Publication Type:Journal Article
- Keywords:
Cystatin C;
Kidney transplantation;
Serum creatinine;
Glomerular filtration rate
- From:
Chinese Journal of Organ Transplantation
2010;31(11):648-650
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether serum cystatin C (SCys C) could be used as an ideal index to assess renal function of renal transplant recipients during posttransplant follow-up.Methods Seventy patients who were followed up for at least 6 months after renal transplantation in our centre were recruited in the study. SCys C and serum creatinine (SCr) were determined during the follow-up period, and glomerular filtration rate (GFR) was measured using an isotope Tc99m DTPA.The correlation between SCys C, SCr and GFR was analyzed. The performance of SCys C and SCr in diagnosing the mild impairment of renal allgraft function (GFR ＜ 1 ml/s) was evaluated using ROC curve. Results Both SCys C and SCr had a linear negative correlation with GFR (r = -0. 82 and -0. 66 respectively, P＜0. 01 ). The sensitivity, specificity and positive predictive values (PPV) of SCys C for diagnosing the mild impairment of renal allgraft function were higher than those of SCr,but the AUC of SCys C did not differ from that of SCr significantly (0. 935 vs. 0. 877, P＞0. 05).Conclusion SCys C could be used an ideal index to evaluate the allograft renal function for its better correlation with actual GFR.
