Therapeutic effects of lung transplantation for diffuse pulmonary disease
10.3760/cma.j.issn.0254-1785.2010.11.009
- VernacularTitle:肺移植治疗肺弥漫性病变的疗效观察(附37例报告)
- Author:
Min ZHOU
;
Yanhong ZHU
;
Jingyu CHEN
;
Bo WU
;
Ji ZHANG
;
Mingfeng ZHENG
;
Yijun HE
- Publication Type:Journal Article
- Keywords:
Lung Transplantation;
Diffuse pulmonary disease
- From:
Chinese Journal of Organ Transplantation
2010;31(11):672-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effects of lung transplantation for diffuse pulmonary disease. Methods From September 2002 to April 2009, lung transplantation was performed on 72 cases in our hospital. Thirty-seven cases of these recipients were suffered from diffuse pulmonary disease, including idiopathic pulmonary fibrosis (30/37), pneumosilicosis (4/37), vascular leiomyoma (2/37) ,diffuse panbronchiolitis (1/37),30 males and 7 females with age ranging from 22 to 73 years old (mean 52.9 ± 13.2). All the patients received pulmonary function test and echocardiography (ECHO) to test the pulmonary artery systolic pressure before transplantation and artery blood gas to calculate the oxygenation index (PaO2/FiO2 ). Results The systolic pulmonary artery pressure (Ppa,syst) was monitored by Swan-Gans catheterization one week post-transplant, and decreased significantly from 54. 30 ± 17. 41 to 41.52 ± 9. 36 mm Hg (P＜0. 05). Simultaneously, oxygenation index was improved from 185. 89 ± 77. 25 to 392. 12 ± 98. 23 (P＜0. 05). The pulmonary function was also improved significanzly one month post-operation. The volume in the first second was improved from (1.33 ± 0. 64) to (1.81 ± 0. 57) L, and the diffusion capacity of carbonmonoxide was increased from (2. 87 ± 1.26) to (4. 22 ± 2. 05) L. Conclusion Lung transplantation is feasible and efficient to deal with diffuse pulmonary disease.
