Diabetes mellitus or insulin resistance resulted from intrauterine growth retardation related epigenetic transformation
10.3760/cma.j.issn.1673-4408.2010.06.019
- VernacularTitle:部分相关基因的表观遗传学改变与宫内发育迟缓者成年期糖尿病易患性
- Author:
Yaqin LIANG
- Publication Type:Journal Article
- Keywords:
Fetal growth retardation;
Diabetes mellitus;
Epigenesis,Genetic;
Glucose transporter 4
- From:
International Journal of Pediatrics
2010;37(6):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus is poly-genetic inherited disease, which is influenced by both genes and environment. The environment may increase the susceptibility of diabetes mellitus via epigenetic way. While those from the same paternal and maternal imprinted genes in the role of offspring are not identical. Adverse intrauterine environment can be regarded as an integral part of the environment, therefore, intrauterine growth retardation may cause fetal epigenetic changes, which are also called imprinted genes. This paper will introduce the latest researches of the diabetes mellitus or insulin resistance-related imprinted genes,for example,GLUT4, IGF-2/H19,PGC-1 α and so on, to explore the relevant therapeutic targets of diabetes mellitus or insulin resistance at the level of epigenetics.
