Expression and its significance of vascular endothelial growth factor in patients with obstructive sleep apnea-hypopnea syndrome
10.3760/cma.j.issn.0254-9026.2010.11.011
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者血管内皮生长因子的表达及其意义
- Author:
Qichang LIN
;
Lingyan SHI
;
Jianchai HUANG
;
Dongyu HUANG
;
Biying WANG
;
Jianming ZHAO
;
Ruiqiang HUANG
- Publication Type:Journal Article
- Keywords:
Sleep apnea,obstructive;
Vascular endothelial growth factor;
Reverse transcription polymerase chain reaction;
Enzyme-linked immunosorbent assay
- From:
Chinese Journal of Geriatrics
2010;29(11):908-911
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression level change of vascular endothelial growth factor (VEGF) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), and to explore the relationships of VEGF expression with OSAHS, OSAHS related cardiovascular and cerebrovascular diseases. Methods Polysomnography (PSG) was used to conduct sleep apnea monitoring in 24 OSAHS patients from 6OSAHS popular families and 48 healthy controls with normal physical examination results. The expression of VEGF mRNA was examined by reverse transcriptionpolymerase chain reaction (RT-PCR) analysis, meanwhile, the level of VEGF in plasma was measured VEGF mRNA in PBMC were significantly higher in simple OSAHS group [plasma levels: (205.75±2.79) pg/ml; mRNA: 0. 61±0. 02] than in control group [(168.72±4.64) pg/ml; 0. 47±0. 02,cardiovascular and cerebrovascular diseases group [(288.74 ± 2.73) pg/ml, 1.16 ± 0. 03] than in simple OSAHS group [ ( 205.75 ± 2.79 ) pg/ml, 0. 61 ± 0.02, P ＜ 0. 01]. ( 2 ) There was a positive correlation of the levels of VEGF in plasma and mRNA with AHI as well as systolic and diastolic blood pressure in early morning. There was a negative correlation of the level of VEGF in plasma and VEGF mRNA with the lowest saturation of blood oxygen. There was a positive correlation of the level of VEGF mRNA with AHI as well as systolic and diastolic blood pressure in early morning.Conclusions The level of VEGF in OSAHS significantly increases, which may play a role in the pathophysiology of OSAHS and OSAHS related cardiovascular and cerebrovascular diseases.
