Clinical characteristics and prognostic analysis of primary testicular lymphoma
10.3760/cma.j.issn.1000-6702.2010.11.016
- VernacularTitle:原发睾丸淋巴瘤的临床特点及预后因素分析
- Author:
Cuicui ZHAO
;
Huaqing WANG
;
Kai FU
;
Zhengzi QIAN
;
Xianming LIU
;
Huilai ZHANG
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
Primary testicular lymphoma;
B cell lymphoma;
Clinical character;
Prognosis
- From:
Chinese Journal of Urology
2010;31(11):777-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical features and prognostic factors of primary testicular lymphoma (PTL). Methods A retrospective review was performed based on the clinical records of 33 PTL cases treated at Tianjin Medical University Cancer Hospital from June 1977 to May 2009.Drawing survival curves by Kaplan-Meier method, using Log-rank test to the univariate analysis, and multivariate analysis by COX regression model to evaluate independent prognostic factors. Results The median age of patients was 62 years at presentation(range 33-81 years). Painless testicular swelling was the initial symptom. The majority of histological subtype was B cell lymphoma, 48% of which was diffuse large B-cell non-Hodgkin's lymphoma. By postoperative chemotherapy and/or radiotherapy, 23 patients achieved complete remission and 7 achieved partial remission, with a median follow-up of 23 months (4-231 months). The 5 years and 10 years of overall survival was 39.1% and 19.5%. The effect of patients who received chemotherapy≥4 cycles and B cell lymphoma patients combination with Rituximab were better. In multivariate analysis, Ann Arbor stage, B symptoms, age of patient and number of extranode site were independent prognostic factors of survival. Conclusions Primary non-Hodgkin lymphoma should be treated with multi-modality strategies. Treatment with doxorubicin-based chemotherapy after orchiectomy should be recommended. Ann Arbor stage, B symptoms, age of patient and number of extranode site were independent prognostic factors of survival in PTL.
