Half-effective target plasma concentration of remifentanil inhibiting airway response when combined with propofol by TCI in patients undergoing fiberoptic bronchoscopy
10.3760/cma.j.issn.0254-1416.2010.07.008
- VernacularTitle:复合TCI异丙酚时瑞芬太尼抑制纤维支气管镜检查患者气道反应的半数有效血浆靶浓度
- Author:
Jun ZHOU
;
Chengxiang YANG
;
Shanglong YAO
;
Jiying ZHONG
;
Xingtian LIANG
;
Hanbing WANG
- Publication Type:Journal Article
- Keywords:
Propofol;
Piperidines;
Drug delivery systems;
Bronchoscopy;
Dose-response relationship,drug
- From:
Chinese Journal of Anesthesiology
2010;30(7):790-792
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the half-effective target plasma concentration(EC50)of remifentanil inhibiting airway response when combined with propofol by TCI in patients undergoing fiberoptic bronchoscopy.Methods Forty ASAⅠorⅡ patients,aged 20-64 yr, undergoing elective fiberoptic bronchoscopy, were randomly divided into 2 groups (n = 20 each).Anesthesia was performed with TCI of remifentanil and propofol in both groups. The target effect site concentration of propofol was 3 μg/ml.The target effect site concentration of remifentanil was determined by up-and-down sequential hial. The target effect site concentration of remifentanil was set at 5 μg/ml in the first patient and the ratio of the target concentrations between the two consecutive patients was 1.1. BIS ≤ 60 was defined as the suitable depth of anesthesia in group A.The airway response≤grade Ⅱ was defined as the suitable depth of anesthesia in group B. The EC50 and 95% confidence interval (CI) required to inhibit the airway response were calculated in the two groups.Results The EC50 and 95% CI of remifentanil required to inhibit the airway response were 4.50μg/L (95% CI 3.88-5.36 μg/L)in group A and 4.10μg/L(95% GI 3.31-5.00 μg/L) in group B. The EC50 of remifentanil inhibiting airway response was significantly higher in group A than in group B. Conclusion The EC50 of remifentanil inhibiting airway response is 4.10 μg/L when combined with propofol by TGI (effect site concentration 3μg/ml)in patients undergoing bronchoscopy. BIS is not a suitable index assessing the depth of propofol-remifentanil anesthesia.
