HCC recurrence is an important factor of HBV re-infection in liver transplant recipients

VernacularTitle:肝移植术后肝癌复发对HBV再感染的影响
Author: Pengji GAO ; Xisheng LENG ; Guangming LI ; Lei HUANG ; Dong WANG ; Jie GAO ; Jiye ZHU
Publication Type:Journal Article
Keywords: Liver transplantation; Hepatitis B virus; Immunoglobulins; Neoplasm recurrence,local
From: Chinese Journal of General Surgery 2010;25(11):916-918
CountryChina
Language:Chinese
Abstract: Objective To study the risk factors of hepatitis B virus re-infection after liver transplantation. Methods We retrospectively analyze the data of 285 patients who underwent liver transplantation for hepatitis B related diseases basing on data collected during a follow-up of at least 6 months. Results The postoperative follow-up ranges from 6 to 59 months of all the 285 cases after liver transplantation. There were 10 patients diagnosed as hepatitis B virus re-infection after liver transplantation leading to a 3.5% re-infection rate. There were 9 patients being diagnosed as HCC recurrence before HBV re-infection was identified. Patients with HCC recurrence suffered from higher HBV re-infection rate than other patients, and HBsAg and HBcAg was detected in one of the 13 metastatic HCC specimens.Conclusions HBIg combined with nucleotide analogue can effectively prevent HBV re-infention. HCCrecurrence is an important risk factor to HBV re-infection after liver transplantation.