Determination of drug release in vitro of atractylenolide Ⅰ liposome by RP-HPLC
10.3760/cma.j.issn.1673-4246.2010.06.033
- VernacularTitle:RP-HPLC法测定白术内酯Ⅰ脂质体的体外释放度
- Author:
Zhihao LI
;
Xuesong ZHU
;
Fang ZHENG
- Publication Type:Journal Article
- Keywords:
Atractylenolide Ⅰ;
Liposomes;
Release in vitro
- From:
International Journal of Traditional Chinese Medicine
2010;32(6):533-534
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a RP-HPLC method for the determination of drug release in vitro of atractylenolide Ⅰ liposomes. Methods The release behavior of the drug from liposomes was studied by the third method for dissolution. ZORBAX C18 column (4.6 mm × 250 mm, 5 μm) was used with a mobile phase of Methanol-Acetonitrile-0.2% from liposomes in vitro fitted the log-normal distribution equation and had a property of sustained release. Conclusion The method is simple, fast and selective. It is suitable for the determination of release profile in vitro of atractylenolide Ⅰ liposomes.
