Efficacies of the Modified Ultrafiltration and Peritoneal Dialysis in Removing Inflammatory Mediators After Pediatric Cardiac Surgery.
- Author:
Si Chan SUNG
1
;
Min Ho JUNG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Dong-A University, Korea. scsung@mail.donga.ac.kr
- Publication Type:Original Article
- Keywords:
Cardiopulmonary bypass;
Complement;
C3a;
Interleukin-6
- MeSH:
Anaphylatoxins;
Body Weight;
Capillary Leak Syndrome;
Cardiopulmonary Bypass;
Complement Activation;
Complement C3a;
Complement System Proteins;
Cytokines;
Heart Septal Defects, Ventricular;
Humans;
Infant;
Interleukin-6;
Peritoneal Dialysis*;
Plasma;
Radioimmunoassay;
Thoracic Surgery*;
Ultrafiltration*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2001;34(10):745-753
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cardiopulmonary bypass induces an acute systemic inflammatory response mediated by complement activation and cytokine release. This response is likely to cause capillary leak syndrome and organ dysfunction in infants. Removing harmful cytokines and complement anaphylatoxins after cardiopulmonary bypass may attenuate this response. This study was conducted to see if the modified ultrafiltration and postoperative peritoneal dialysis can reduce plasma inflammatory mediators in pediatric cardiac surgery. MATERIAL AND METHOD: 30 infants (age 1.1 to 12.6 months) who underwent closures of ventricular septal defect using cardiopulmonary bypass (CPB) were enrolled in this study. These patients were divided into three groups; 10 patients selected randomly underwent modified ultrafiltration (Group U), 10 with small body weights (
