Effect of insulin-like growth factor-1 on intercellular adhesion molecule-1 expression in rat model of congestive heart failure
10.3760/cma.j.issn.0254-9026.2010.11.020
- VernacularTitle:胰岛素样生长因子对心力衰竭大鼠心肌细胞黏附分子1表达的影响
- Author:
Mei HONG
;
Gang HU
;
Xiang LU
;
Xiulan SUN
;
Wenzhi HU
;
Haibo ZHOU
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor Ⅰ;
Heart failure,congestive;
Angiotensin Ⅱ;
Intercellular adhesion molecule -1
- From:
Chinese Journal of Geriatrics
2010;29(11):940-943
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of insulin-like growth factor-1 (IGF-1) on intercellular adhesion molecule-1 (ICAM-1) expression in rat model with congestive heart failure (CHF). Methods The model of CHF in male Sprague-Dawley rat was established using subcutaneous injection of isoproterenol. The rats were randomized into model group (n = 10),angiotensin converting enzyme inhibitors (ACEI) group ( n=10) and IGF- 1 group ( n = 10). The rats injected with saline were used as normal controls (n=10). The haemodynamic parameters of rats in each group were detected. The concentration of plasma angiotensin Ⅱ (Ang Ⅱ ) and expression of ICAM-1 in rat myocardium were determined by radioimmunoassay and immunohistochemistry,respectively. Results Compared with model group, ACEI and IGF-1 could rescue the diversities of hemodynamic parameters. In addition, ACEI and IGF-1 could also significantly down-regulated concentration of plasma Ang Ⅱ and inhibited ICAM-1 expression. Compared with ACEI, IGF-1 more significantly inhibited ICAM-I expression (0. 804 ± 0. 024 vs. 1. 254 ± 0. 059) and down-regulated concentration of plasma AngⅡ [(369.2±65.0) μg/L vs. (384.4±56.2) μg/L]. Conclusions IGF-1 can suppress ICAM-1 expression in rat model with CHF induced by isoproterenol. This effect may be related to inhibiting activation of RAS system.
