GABAA receptors and fragile X syndrome
10.3760/cma.j.issn.1673-4408.2010.06.029
- VernacularTitle:GABAA受体与脆性X综合征
- Author:
Yanyan WANG
- Publication Type:Journal Article
- Keywords:
Fragile X syndrome;
GABAA receptors;
Phenotype
- From:
International Journal of Pediatrics
2010;37(6):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Fragile X syndrome is a common cause of inherit mental retardation,GABAA receptors are the major inhibitory neurotransmitter receptros in the mammalian central nervous system, implicated in anxiety,depression, epilepsy, sleeping problem, learning and memory, and so on. Several researches indicated that the GABAergic system, in particular the GABAA receptors might be related to the phenotype of fragile X syndrome. An altered expression of certain subunits of the GABAA receptors may cause the neurological and behavioural changes of the fragile X syndrome. Therefore,the GABAA receptors can be a novel therapeutic target for treatment of fragile X syndrome.
