Expression of PPARγand RXRα in cholangiocarcinoma and its impact on prognosis
10.3760/cma.j.issn.1007-8118.2010.11.012
- VernacularTitle:过氧化物酶体增长因子活化受体γ与维甲酸类X受体在胆管癌中的表达及其对预后的影响
- Author:
Bing LIU
;
Wenbin WANG
;
Ming LIU
;
Anfeng WANG
;
Yuanqiu XU
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
PPARγ;
RXRα;
Prognosis;
Metastasis
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(11):835-838
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of peroxisome proliferator-activated receptor γ(PPARγ)and retinoid x receptorα(RXRα)in cholangiocarcinoma to explore its relation to clinicopathological factors and investigate its impact on prognosis.Methods Expression of PPARγ and RXRα was detected by immunohistochemistry in 69 cases of cholangiocarcinoma and 12 non-tumor cases.The relation of PPARγ and RXRα expression to clinicopathological parameters and prognosis was determined.Results The expression rates of PPARγ in 69 cases of cholangiocarcinoma and 12 non-tumor cases were 59.4% and 0, respectively(P＜0.05).The expression rates of RXRα in 69 cases of cholangiocarcinoma and 12 non-tumor cases were 78.3% and 20%, respectively.There were significant differences between the 2 groups in PPARγ and RXRα expression.PPARγ expression was associated with TNM clinical stages and lymph node metastasis.According to univariate survival analysis,PPARγ expression was correlated with poor prognosis(P＜0.05).There was positive correlation between PPARγ and RXRα.Conclusion The expression of PPARγis significantly correlated with the clinicopathological characteristics and biological behaviors of cholangiocarcinoma.PPARγ and RXRα expression may play an important role during tumorigenesis.
