The robe of transcription factors in genetics mechanism of congenital atrioventricular septal defect
10.3760/cma.j.issn.1673-4408.2010.06.002
- VernacularTitle:转录因子在先天性房室隔缺损遗传学机制中的作用
- Author:
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Transcription factors;
Atrioventricular septal defect;
Genetics
- From:
International Journal of Pediatrics
2010;37(6):555-557
- CountryChina
- Language:Chinese
-
Abstract:
Atrioventricular septal defect (AVSD)is a frequently diagnosed congenital heart malformation affecting the atrioventricular valves and septa. Heart transcription factors play fundamental roles in atrioventricular valves development and atrioventricular septa formation. Now cardiac transcription factors ( GATA4, NKX2. 5,TBX5 ,ZIC3)have been identified to involve in the pathogenesis of AVSD in humans. Their abnormal expression or function change may cause atrioventricular valve and septa developmental anomalies. Here we review advances in the understanding of the relationship between these transcription factors and AVSD.
