The effect of airway smooth muscle cell on asthma airway remodeling
10.3760/cma.j.issn.1673-4408.2010.06.007
- VernacularTitle:气道平滑肌细胞在哮喘气道重塑中的作用
- Author:
Miao LI
- Publication Type:Journal Article
- Keywords:
Airway remodeling;
Airway smooth muscle;
Asthma
- From:
International Journal of Pediatrics
2010;37(6):571-574
- CountryChina
- Language:Chinese
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Abstract:
Airway remodeling is the result of chronic inflammation, which including airway wall thickening, matrix and collagen deposition, epithelial hyperplasia and fibrosis, smooth proliferation and hypertrophy,fibroblast proliferation, and mucus glands and goblet cell proliferation, micrangium generation and other pathological changes. Airway smooth muscle change is known as the reason of airway hyper - responsiveness and asthma aggravating. There are many factors which can induce airway smooth muscle hypertrophy and proliferation, such as inflammation, cytokines,extracellular matrix and genetic factors. In addition, recent researches reveal the airway smooth muscle is also an important source of inflammation. In this paper the latest opinion of the role of asthma airway smooth muscle in the airway remodeling were elaborated,and inhale hormone earlier was suggested.
