A preliminary study on the role of serum tumor necrosis factor alpha levels for diagnosis of early acute rejection after heterototpic rat heart-lung transplantation
- VernacularTitle:血清肿瘤坏死因子α水平在大鼠心肺移植术后早期急性排斥反应诊断中的意义
- Author:
Jianjun WANG
;
Zejian LI
- Publication Type:Journal Article
- Keywords:
Tumour necrosis factor;
Rejection;
Heart;
Lung;
Transplantation,heterologous
- From:
Chinese Journal of Organ Transplantation
1996;17(1):18-20
- CountryChina
- Language:Chinese
-
Abstract:
In this study an acute rejecting model of heterotopic rat heart-lung transplantation was established by using simplified technique of end to side anastomosis of donor ascending aorta with recipient abdominal aorta.The measurements of tumor necrosis factor alpha(TNF-α)in serum of rats by Sandwich-ELISA method were taken on the 3rd,5th,7th days respectively after operation.The results of this study with histological examination showed that TNF-α serum levels were increased during acute rejection episodes.and it might be a useful indicator for diagnosis of allograft rejection.
